Bioconjugation Service

Bioconjugation Service at AxisPharm

Bioconjugation is the process of linking molecules/polymers or biomolecules/biopolymers together by covalent bonds. Conjugation can enhance drug efficacy by improving pharmacokinetic and pharmacodynamic properties and by reducing plasma protein binding. For instance, introducing polyethylene glycol (PEG) or polysaccharide reduces toxicity and improves solubility and stability.

AxisPharm offer our clients with affordable and high quality custom bioconjugation service that covers:

Early de-risking and optimization

Process development and optimization

Formulation development

Analytical method development

Drug substance manufacture

Drug product manufacture

Payload and linker manufacturing

Our bio conjugation service delivers affordable and high-quality custom bioconjugation service, using combinations of payloads, linkers, and conjugation methods.

Antibody-Drug Conjugates (ADCs)

Antibody-Oligonucleotide Conjugates (AOCs)

Protein-drug Conjugation

Fluorophore Conjugation (products: fluorescent dyes)

Biotin conjugation (products: biotin peg)

Polymer–drug conjugation (products: polymer peg)

Polymer-drug-target ligand conjugation

PEGylation and cross-linking

Cysteine-based conjugation

Lysine-based conjugation

Thio-engineered antibody

Carbohydrate-based conjugation

Unnatural amino acids-based conjugation (product: amino peg)

Analytical – AxisPharm has the analytical tools and experience that are critical for this field. We are equipped with sophisticated mass spectrometers for small and large molecules to analyze and quantify protein, antibody and their conjugates. We routinely use high resolution mass spectrometer on real time analysis of drug-antibody ratio for bioconjugation synthesis, process optimization and quality control. Please click for real time analysis case study.

Synthetic Chemistry and Biology Expertise – AxisPharm has a large collection of ADC linker, such as PEG linker, Peptide Linker, Sugar Liner, Dye Probe in stock and has extensive experience in synthesis, purification and characterization of both small and large molecules to support bioconjugation R&D.

 https://axispharm.com/bioconjugation-service/