Contrast Media Manufacturing Company
Contrast Media Manufacturing Company
For the purpose of medical imaging, a certain substance is introduced into the human body to change the image contrast of local tissues of the body. This introduced substance is Contrast Media, also known as Contrast Agents. As the first Contrast Media manufacturer in China, Beilu Pharma, as one of the most professional contrast media companies, launched the domestic MRI Contrast Media Gadopentetate Dimeglumine Injection in 1992, which broke the foreign products monopoly and filled the domestic gap. As a well-known contrast media company, we could provide a broad portfolio stems Contrast Media across CT/X-ray and MRI modalities, and own the EU standard manufacturing facilities.
Types of Contrast Media in Beilu Pharma
MRI CONTRAST MEDIA
Magnetic Resonance Imaging (MRI)Contrast Media is Gadolinium based contrast agent(GBCA). It is an intravenous injection, mainly used to enhance the image quality of internal organs, blood vessels and tissues during MRI examinations. GBCA contains gadolinium, which is connected to each other through carrier molecules to form a chelating agent. According to the different chemical structures, this contrast medium can be divided into two categories: linear and macrocyclic. The linear structure of the imaging agents is easier to release gadolinium ions, and the macrocyclic structure of the contrast material is more stable and less likely to release gadolinium ions.
CT/X-RAY CONTRAST MEDIA
Iodine-containing Contrast Media is one of the common imaging contrast agents used in radiology diagnosis and interventional therapy. It is also a basic diagnosis drug for cardiovascular imaging under X-ray. Currently, the iodinated Contrast Media used for cardiovascular system CT and digital subtraction angiography are all water-soluble organic iodinated contrast materials.
Finished Types of Contrast Media
S. No
Product name
Characteristic
Specification
1
Gadopentetate Dimeglumine Injection
Injectable solution
469mg/ml: 10ml, 12ml, 15ml, 20ml
2
Gadobutrol Injection
Injectable solution
604.72mg/ml: 7.5ml
3
Ammonium iron citrate
Oral granules
3g：0.6g（Fe 129mg）
6g：1.2g（Fe 258mg）
4
Iopamidol Injection
Injectable solution
300mgI/ml: 50ml, 100ml
370mgI/ml: 50ml, 100ml
5
Iodixanol Injection
Injectable solution
270mgI/ml: 100ml
320mgI/ml: 50ml, 100ml
6
Iohexol Injection
Injectable solution
300mgI/ml: 20ml,50ml,75ml, 100ml
350mgI/ml: 20ml, 50ml, 100ml
API & Intermediates Types of Contrast Media
S. No
Products
CAS NO.
Packings
Classification
1
Iohexol
66108-95-0
25kg
Contrast agent
2
Iodixanol
92339-11-2
25kg
Contrast agent
3
Iopromide
73334-07-3
25kg
Contrast agent
4
Iopamidol
60166-93-0
25kg
Contrast agent
5
Ioversol
87771-40-2
25kg
Contrast agent
6
Gadopentetate Monomeglumine
92923-57-4
25kg
Contrast agent
7
Gadopentetate Dimeglumine
86050-77-3
25kg
Contrast agent
8
Gadobutrol
138071-82-6
25kg
Contrast agent
9
Calcobutrol
151878-23-8
2kg
Excipients
10
Repaglinide
135062-02-1
10kg
Anti-diabetic
11
Diethylenetriaminepentaacetic acid ( Pentaacetic Acid)（DTPA）
67-43-6
2.5kg
Intermediates
12
Iopamidol Intermediate (order based) 5-Amino-2,4,6-triiodoisophthalic acid
35453-19-1
25kg
Intermediates
Comparison of physicochemical characteristics of commonly used Contrast Media
Contrast media
Osmotic pressure
Viscosity
(Concentration：mg（I）/ml)
(mOsm/kg water）
（cP，37℃）
Iopamidol 300
616
4.7
Ioverol 300
651
5.5
Iohexol 300
672
6.3
Iobitridol 300
695
6
Iodixanol 320
290
11.8
The osmotic pressure of normal people is about 290-300mOsm/kg.
Taking the viscosity of water as 1, when the temperature is 37℃, the relative viscosity of whole blood is 4-5, and the relative viscosity of plasma is 1.6-2.4.
Three factors of renal injury induced by Contrast Media: Osmotic pressure, Viscosity and the total iodine. Reduced iodine intake is a feasible strategy to avoid kidney damage.
