Glycosylation Peptides

A covalent alteration known as peptide glycosylation may enhance the physicochemical characteristics of peptides. Increased bioavailability, increased metabolic stability, targeting particular tissues and organs, decreased clearance rates, improved receptor binding, facilitated active transport across cell membranes (glucose transporters), and preservation of the overall physical properties of peptides (precipitation, aggregation, thermal, and kinetic denaturation) are some benefits of glycosylated peptides.

Glycan Polysaccharides

Many peptides can benefit from simple glycans, which are composed of just one sugar molecule (such as D-galactose, D-glucose, or D-mannose), but in rare circumstances, more complex glycans may be necessary. Site-specific glycosylations of a variety of linear or branched glycan polysaccharides are available from our technical team.

Common Glycosylated Amino Acids

Sugar

Amino Acid

Glycated Amino Acid

Linkage

α-D-Galactose

Serine

Ser(alpha-D-GalNAc)

Tn Antigen

O-linked

α-D-Galactose

Threonine

Thr(alpha-D-GalNAc)

Tn Antigen

O-linked

β-D-Galactose

Serine

Ser(beta-D-GalNAc)

O-linked

β-D-Galactose

Threonine

Thr(beta-D-GalNAc)

O-linked

β-D-Galactose

Serine

Ser(Gal-beta(1-3)GalNAc)

Tf Antigen

O-linked

β-D-Galactose

Threonine

Thr (Gal-beta(1-3)GalNAc)

Tf Antigen

O-linked

β-D-Glucose

Serine

Ser(beta-D-GlcNAc)

O-linked

β-D-Glucose

Threonine

Thr(beta-D-GlcNAc)

O-linked

β-D-Glucose

Asparagine

Asn(beta-D-GlcNAc)

N-linked

β-D-Glucose

Serine

Ser(beta-D-Glc)

O-linked

α-D-Mannose

Serine

Thr(alpha-D-Man)

O-linked

α-D-Mannose

Asparagine

Asn(alpha-D-Man)

N-linked

α-D-Mannose

Serine

Ser(alpha-D-Man)

O-linked

α-D-Mannose

Threonine

Thr(alpha-D-Man)

O-linked