4-Methoxybenzoyl Chloride
Basic Information
Product Name: 4-Methoxybenzoyl Chloride
CAS No.: 100-07-2
EINECS No.: 202-816-4
FEMA No.: 2005
Synonyms: p-anisoyl chloride
Molecular Formula: C8H7ClO2
Molecular Weight: 170.59
Specifications
Appearance: White to pale yellow low-melting solid or liquid
Melting Point: 22–24 °C
Boiling Point: 262–263 °C (760 mmHg, slight decomposition)
Flash Point: 87 °C
Purity: ≥99.0%
Density: 1.260 g/mL (20°C)
Product Description
4 methoxybenzoyl chloride (CAS No.: 100-07-2) is an important anisic acid chemical intermediate widely used in pharmaceutical synthesis and organic reactions. It is typically applied in acylation processes and the preparation of fine chemical derivatives. As a highly reactive acylating agent, this compound serves as a key building block in medicinal chemistry research. It has been documented in the synthesis of stilbene and dihydrostilbene derivatives studied as potential anti-cancer agents, as well as in the preparation of coumarin dimers investigated for potential HIV-1 inhibitory activity. These research applications reflect its value as a versatile electrophilic reagent in advanced organic synthesis.
Applications
• Pharmaceutical intermediate synthesis, including active pharmaceutical ingredient (API) precursors
• Synthesis of stilbene and dihydrostilbene derivatives as potential anti-cancer agents
• Synthesis of coumarin dimers with potential HIV-1 inhibitory activity
• Organic acylation reactions (Friedel-Crafts acylation, esterification, amide bond formation)
• Fine chemical and agrochemical manufacturing
Stability
Avoid contact with humid air, and avoid contact with strong oxidants, water and strong bases.
Solubility
Soluble in acetone and benzene; decomposes upon contact with water and ethanol.
Hazards
H227 – Combustible liquid; H314 – Causes severe skin burns and eye damage; H318 – Causes serious eye damage; H335 – May cause respiratory irritation
Transport Information
UN Number: UN 1760
Hazard Class: Class 8 – Corrosive Substances
Packing Group: II (Medium Danger)
Packaging & Storage
Packaging: 250 kg/drum
Storage: Store in a cool and well-ventilated warehouse. Keep away from heat, moisture, and ignition sources. Avoid contact with water, strong oxidants, and alkaline substances. Use appropriate containment measures for spill control.
